Calreticulin transacetylase: a novel enzyme-mediated protein acetylation by acetoxy derivatives of 3-alkyl-4-methylcoumarins

…, K Chand, A Kathuria, P Singh, N Priya, B Gupta…

Index: Jalal, Sarah; Chand, Karam; Kathuria, Abha; Singh, Prabhjot; Priya, Nivedita; Gupta, Bhavna; Raj, Hanumantharao G.; Sharma, Sunil K. Bioorganic Chemistry, 2012 , vol. 40, # 1 p. 131 - 136

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Citation Number: 5

Abstract

Our earlier investigations culminated in the discovery of a unique membrane-bound enzyme Calreticulin transacetylase (CRTAase) in mammalian cells catalyzing the transfer of acetyl group from polyphenolic acetates (PAs) to certain functional proteins viz. Glutathione S- transferase (GST), NADPH Cytochrome c reductase and Nitric oxide synthase (NOS) resulting in the modulation of their biological activities. In order to develop SAR study, ...