Antiarthritic and supressor cell inducing activity of azaspiranes: structure-function relationships of a novel class of immunomodulatory agents

…, EN Cheeseman, MJ DiMartino, N Hanna…

Index: Badger; Schwartz; Picker; Dorman; Bradley; Cheeseman; DiMartino; Hanna; Mirabelli Journal of Medicinal Chemistry, 1990 , vol. 33, # 11 p. 2963 - 2970

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Citation Number: 44

Abstract

The demonstration of disorders of suppressor cells in animal models of autoimmune and in patients with aut~ immunity~-~ suggests that their regulation may be a rational approach for immunotherapy. If the loss of suppressor cells in patients with autoimmunity is an important link in the causation of the disease (s), therapy directed toward augmenting suppressor mechanisms may be effective in treating the manifestations of autoimmune diseases (eg, ...

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