The hypoglycemic effect of (7R*, 9aS*)-7-phenyl-octahydroquinolizin-2-one in mice.

…, K Higashiyama, J KAMEI, Y FUJII, S OHMIYA

Index: Kubo, Hajime; Kobayashi, Junji; Higashiyama, Kimio; Kamei, Junzo; Fujii, Yuji; Ohmiya, Shigeru Biological and Pharmaceutical Bulletin, 2000 , vol. 23, # 9 p. 1114 - 1117

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Citation Number: 32

Abstract

(-)-Multiflorine (1), which was isolated from leguminous plants, produced a hypoglycemic effect when administered to mice with streptozotocin-induced diabetes.(-)-Multiflorine has an enaminone type conjugation on the A-ring, which is unusual in lupine alkaloids. Proceeding on the assumption that the AB ring is responsible for the activity, several compounds bearing quinolizidin-2-one were synthesized and their hypoglycemic effects were examined. The ...