Rhodotorula minuta-mediated bioreduction of 1, 2-diketones

…, P Cerrutti, MA Galvagno, A Baldessari

Index: Monsalve, Leandro N.; Cerrutti, Patricia; Galvagno, Miguel A.; Baldessari, Alicia Biocatalysis and Biotransformation, 2010 , vol. 28, # 2 p. 137 - 143

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Citation Number: 5

Abstract

Abstract The reduction of cyclic and acyclic 1, 2-diketones was investigated by employing whole cells of the yeast Rhodotorula minuta as biocatalyst. The reactions showed a variable degree of regio-and enantioselectivity depending on the nature of the substrate. In the case of cyclic diketones, the reduction afforded a mixture of diastereomeric diols only. The reduction of acyclic diketones allowed production of both the hydroxy ketone and the diol, ...