Synthesis and functional pharmacological effects on human bronchi of 20-hydroxyeicosatetraenoic acid

A Proteau-Gagne, F St-Jean, C Morin…

Index: Proteau-Gagne; St-Jean; Morin; Gendron; Rousseau; Dory Chemistry of Natural Compounds, 2011 , vol. 46, # 6 p. 841 - 847

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Abstract

We have synthesized 20-hydroxyeicosatetraenoic acid (20-HETE) following a new route and delineated its functional effects in human bronchi. Isometric tension measurements were performed, and they demonstrated that synthetic 20-HETE induced a concentration- ...

~4%

~99%

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