1-Aryl-3-(1-acylpiperidin-4-yl) urea inhibitors of human and murine soluble epoxide hydrolase: structure− activity relationships, pharmacokinetics, and reduction of …

TE Rose, C Morisseau, JY Liu, B Inceoglu…

Index: Rose, Tristan E.; Morisseau, Christophe; Liu, Jun-Yan; Inceoglu, Bora; Jones, Paul D.; Sanborn, James R.; Hammock, Bruce D. Journal of Medicinal Chemistry, 2010 , vol. 53, # 19 p. 7067 - 7075

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Citation Number: 64

Abstract

1, 3-Disubstituted ureas possessing a piperidyl moiety have been synthesized to investigate their structure− activity relationships as inhibitors of the human and murine soluble epoxide hydrolase (sEH). Oral administration of 13 1-aryl-3-(1-acylpiperidin-4-yl) urea inhibitors in mice revealed substantial improvements in pharmacokinetic parameters over previously reported 1-adamantylurea based inhibitors. For example, 1-(1-(cyclopropanecarbonyl) ...