Molecular features of the prazosin molecule required for activation of Transport-P

…, M Walters, S Al-Damluji, CR Ganellin

Index: da Silva, Joaquim Fernando Mendes; Walters, Marcus; Al-Damluji, Saad; Ganellin, C. Robin Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 15 p. 7254 - 7263

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Citation Number: 35

Abstract

Closely related structural analogues of prazosin have been synthesised and tested for inhibition and activation of Transport-P in order to identify the structural features of the prazosin molecule that appear to be necessary for activation of Transport-P. So far, all the compounds tested are less active than prazosin. It is shown that the structure of prazosin appears to be very specific for the activation. Only quinazolines have been found to ...