e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Tetrahedron

A facile synthesis of (S)-felodipine

K Kwon, JA Shin, HY Lee

Index: Tetrahedron, , vol. 67, # 52 p. 10222 - 10228

Full Text: HTML

Citation Number: 4

Abstract

... Please enable JavaScript to use all the features on this page. Tetrahedron. Volume 67, Issue 52, 30 December 2011, Pages 10222–10228. Organic Synthesis - 2011: Perspective, Journeys and Accounts, Part II. ... 1, 54% (1/1), 80 b. 2, 52% (1/1), 84. 3, 44% (1/1), —. a ...

(2R)-1-(phenylthio)-3-(tetrahydro-2H-pyran-2-yloxy)propan-2-yl 2-(2,3-dichlorobenzylidene)-3-oxobutanoate Structure

(2R)-1-(phenylt...

~%

5-O-ethyl 3-O-methyl (4R)-4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate Structure

5-O-ethyl 3-O-m...

(4S)-3-ethyl 5-(1-(phenylthio)-3-(tetrahydro-2H-pyran-2-yloxy)propan-2-yl) 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate Structure

(4S)-3-ethyl 5-...

~%

5-O-ethyl 3-O-methyl (4R)-4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate Structure

5-O-ethyl 3-O-m...

(R)-3-ethyl 5-((R)-1-hydroxy-3-(phenylthio)propan-2-yl) 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate Structure

(R)-3-ethyl 5-(...

Sodium Methylate Structure

Sodium Methylate

~%

5-O-ethyl 3-O-methyl (4R)-4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate Structure

5-O-ethyl 3-O-m...

Felodipine 3,5-Dimethyl Ester Structure

Felodipine 3,5-...

N/A Structure

~%

Felodipine Structure

3-ethyl 5-((2S)-1-((4-methyl-N-phenylphenyl)sulfonamido)-3-((tetrahydro-2H-pyran-2-yl)oxy)propan-2-yl) 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate Structure

3-ethyl 5-((2S)...

~%

Felodipine Structure

Ethyl (2Z)-3-amino-2-butenoate Structure

Ethyl (2Z)-3-am...

~%

Felodipine Structure

Synthesis of the enantiomers of felodipine and determination...

[Tetrahedron Letters, , vol. 30, # 46 p. 6423 - 6426]

Determination of the absolute configuration of biologically ...

[Chemical and Pharmaceutical Bulletin, , vol. 42, # 9 p. 1968 - 1970]

Determination of the absolute configuration of biologically ...

[Chemical and Pharmaceutical Bulletin, , vol. 42, # 9 p. 1968 - 1970]

Enantioselective Retention of 4??Aryl??1, 4??dihydropyridine...

[Helvetica Chimica Acta, , vol. 83, # 4 p. 767 - 776]

A facile synthesis of (S)-felodipine

[Kwon, Kuktae; Shin, Jung A.; Lee, Hee-Yoon Tetrahedron, 2011 , vol. 67, # 52 p. 10222 - 10228]