Chinese Chemical Letters

Synthesis and cytotoxicity studies of quinoline-3-carbonitrile derivatives

SL Zhang, X Zhai, SJ Zhang, HH Yu, P Gong

Index: Zhang, Shu Lan; Zhai, Xin; Zhang, Shi Jiao; Yu, Hong Hao; Gong, Ping Chinese Chemical Letters, 2010 , vol. 21, # 8 p. 939 - 942

Full Text: HTML

Citation Number: 8

Abstract

A series of quinoline-3-carbonitrile derivatives were designed and synthesized. Their cytotoxicity in vitro against four cancer cell lines (A549, HT-29, MDA-MB-231 and SMMC- 7721) were evaluated by standard MTT assay. The pharmacological results showed that most of the prepared compounds displayed excellent selective cytotoxicity toward SMMC- 7721 cell line. Among them, compounds 7c, 7e, 11b, 11f and 11g were more active than ...