Chemo??and Stereoselective Iron??Catalyzed Hydrosilylation of Ketones

…, S Zhou, S Das, K Junge, M Beller

Index: Das, Shoubhik; Addis, Daniele; Zhou, Shaolin; Junge, Kathrin; Beller, Matthias Journal of the American Chemical Society, 2010 , vol. 132, # 6 p. 1770 - 1771

Full Text: HTML

Citation Number: 77

Abstract

Abstract The reduction of ketones with polymethylhydrosiloxane (PMHS) gives the corresponding alcohols in good to excellent yield applying iron-based catalyst systems. In the case of prochiral ketones, the use of Fe (OAc) 2/(S, S)-Me-DuPhos leads to high enantioselectivity up to 99% ee. The reaction proceeds in the presence of several functional groups such as esters, halides as well as conjugated double bonds, with high ...