A series of tricyclic oxazines, namely, the 4-substituted 2H-naphth [1, 2-b]-1, 4-oxazines, have been synthesized and assayed for dopamine agonist activity. One of the members of this series, compound (+) VII-16, was found to be a remarkably potent agonist in vivo when tested in the standard 6-hydroxydopamine lesioned rat assay. The absolute configuration of the compound corresponds to that found in the active isomer of apomorphine. Its activity at ...
![(4aR,10bR)-3,4,4a,5,6,10b-hexahydro-9-methoxy-4-propyl-2H-naphth[1,2-b]-1,4-oxazine hydrochloride Structure](https://image.chemsrc.com/caspic/388/88058-72-4.png)
