Aryl Biphenyl??3??ylmethylpiperazines as 5??HT7 Receptor Antagonists

…, J Tae, M Yeom, B Moon, XP Huang, BL Roth…

Index: Kim, Jeeyeon; Kim, Youngjae; Tae, Jinsung; Yeom, Miyoung; Moon, Bongjin; Huang, Xi-Ping; Roth, Bryan L.; Lee, Kangho; Rhim, Hyewhon; Choo; Chong, Youhoon; Keum, Gyochang; Nam, Ghilsoo; Choo, Hyunah ChemMedChem, 2013 , vol. 8, # 11 p. 1855 - 1864

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Citation Number: 5

Abstract

Abstract The 5-HT 7 receptor (5-HT 7 R) is a promising therapeutic target for the treatment of depression and neuropathic pain. The 5-HT 7 R antagonist SB-269970 exhibited antidepressant-like activity, whereas systemic administration of the 5-HT 7 R agonist AS-19 significantly inhibited mechanical hypersensitivity and thermal hyperalgesia. In our efforts to discover selective 5-HT 7 R antagonists or agonists, aryl biphenyl-3-ylmethylpiperazines ...