Bioorganic & medicinal chemistry

Synthesis and antihyperglycemic activity of suitably functionalized 3H-quinazolin-4-ones

VJ Ram, BK Tripathi, AK Srivastava

Index: Ram, Vishnu Ji; Farhanullah; Tripathi, Brajendra K.; Srivastava, Arvind K. Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 11 p. 2439 - 2444

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Citation Number: 98

Abstract

A series of 2-sec-amino-3H-quinazolin-4-ones (4a–p) and 4-sec-amino-2- chloroquinazolines (5a–b) have been synthesized by nucleophilic substitution reaction of 2- chloro-4 (3H)-quinazolones (3) and 2, 4-dichloroquinazolines (2) with amines, respectively. Most of the synthesized compounds were evaluated for antihyperglycemic activity but only 4a, b, d, j, o displayed significant reduction in blood glucose level in streptozotocin and ...