Exploration of a series of 5-arylidene-2-thioxoimidazolidin-4-ones as inhibitors of the cytolytic protein perforin

…, CK Miller, PD O'Connor, M Bull, N Helsby…

Index: Spicer, Julie A.; Lena, Gersande; Lyons, Dani M.; Huttunen, Kristiina M.; Miller, Christian K.; O'Connor, Patrick D.; Bull, Matthew; Helsby, Nuala; Jamieson, Stephen M. F.; Denny, William A.; Ciccone, Annette; Browne, Kylie A.; Lopez, Jamie A.; Rudd-Schmidt, Jesse; Voskoboinik, Ilia; Trapani, Joseph A. Journal of Medicinal Chemistry, 2013 , vol. 56, # 23 p. 9542 - 9555

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Citation Number: 9

Abstract

A series of novel 5-arylidene-2-thioxoimidazolidin-4-ones were investigated as inhibitors of the lymphocyte-expressed pore-forming protein perforin. Structure–activity relationships were explored through variation of an isoindolinone or 3, 4-dihydroisoquinolinone subunit ...