Heteroannulation of 6-polyfluoroalkyl-2-thiouracils

…, VI Saloutin, ON Chupakhin, MA Kravchenko

Index: Khudina; Ivanova; Burgart; Slepukhin; Saloutin; Chupakhin; Kravchenko Russian Chemical Bulletin, 2013 , vol. 62, # 4 p. 1060 - 1065 Izvestiya Akademii Nauk. Seriya Khimicheskaya, 2013 , # 4 p. 1059 - 1064,6

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Abstract

Abstract A multi-component double Mannich cyclocondensation of 6-polyfluoroalkyl-2- thiouracils with formalin and heterocyclic amines (2-aminopyridine, 2-aminopyrimidine, 4- aminoantipyrine) proceeded regiospecifically at the C= S and NH centers giving rise to 3- hetaryl-8-polyfluoroalkylpyrimido [2, 1-b][1, 3, 5] thiadiazines. The regioisomeric structure of the products was established by X-ray crystallography, IR and NMR spectroscopy, GLC- ...