Synthesis and antiviral evaluation of benzimidazoles, quinoxalines and indoles from dehydroabietic acid

T Fonseca, B Gigante, MM Marques, TL Gilchrist…

Index: Fonseca, Tatiana; Gigante, Barbara; Marques, M. Matilde; Gilchrist, Thomas L.; De Clercq, Erik Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 1 p. 103 - 112

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Citation Number: 142

Abstract

Several heterocycles, such as benzimidazoles, quinoxalines and indoles incorporated into a hydrophenanthrene and naphthalene skeleton, were synthesised from two useful ortho- bromonitro precursors derived from dehydroabietic acid: methyl 12-bromo-13-nitro- deisopropyldehydroabietate and methyl 12-bromo-13, 14-dinitro- deisopropyldehydroabietate. The new heterocycles were evaluated for their activity in vitro ...