Synthesis, Structure− Activity Relationship, and Mode-of-Action Studies of Antimalarial Reversed Chloroquine Compounds

SJ Burgess, JX Kelly, S Shomloo, S Wittlin…

Index: Burgess, Steven J.; Kelly, Jane X.; Shomloo, Shawheen; Wittlin, Sergio; Brun, Reto; Liebmann, Katherine; Peyton, David H. Journal of Medicinal Chemistry, 2010 , vol. 53, # 17 p. 6477 - 6489

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Citation Number: 35

Abstract

We have previously shown that a “reversed chloroquine (RCQ)” molecule, composed of a chloroquine-like moiety and a resistance reversal-like moiety, can overcome chloroquine resistance in P. falciparum (Burgess, SJ; Selzer, A.; Kelly, JX; Smilkstein, MJ; Riscoe, MK; Peyton, DHJ Med. Chem. 2006, 49, 5623. Andrews, S.; Burgess, SJ; Skaalrud, D.; Kelly, JX; Peyton, DHJ Med. Chem. 2010, 53, 916). Here, we present an investigation into the ...