The Journal of organic chemistry

Synthesis of Disubstituted Imidazo [4, 5-b] pyridin-2-ones

JT Kuethe, A Wong, IW Davies

Index: Kuethe, Jeffrey T.; Wong, Audrey; Davies, Ian W. Journal of Organic Chemistry, 2004 , vol. 69, # 22 p. 7752 - 7754

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Citation Number: 39

Abstract

Regioselective palladium-catalyzed amination of 2-chloro-3-iodopyridine followed by a subsequent palladium-catalyzed amination leads to 2, 3-diaminopyridines. Treatment with triphosgene affords highly functionalized unsymmetrical imidazo [4, 5-b] pyridin-2-ones in just three synthetic steps. A two-step synthesis of pseudosymmetrically disubstituted imidazo [4, 5-b] pyridin-2-ones, 1, 4-disubstituted pyrido [2, 3-b] pyrazinediones, and 1, 3- ...