Synthesis and anti-inflammatory effects of a series of novel 7-hydroxycoumarin derivatives

…, A Goulas, LJ Moilanen, M Haukka, P Vainiotalo…

Index: Timonen, Juri M.; Nieminen, Riina M.; Sareila, Outi; Goulas, Antonis; Moilanen, Lauri J.; Haukka, Matti; Vainiotalo, Pirjo; Moilanen, Eeva; Aulaskari, Paula H. European Journal of Medicinal Chemistry, 2011 , vol. 46, # 9 p. 3845 - 3850

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Citation Number: 35

Abstract

A number of 7-hydroxycoumarins have been synthesised by Pechmann cyclisation using differently substituted resorcinols employing perchloric acid as the condensing agent. All the compounds have been characterised by analytical and spectroscopic methods. The anti- inflammatory properties were tested with LPS-induced inflammation in J774 macrophages. Expression of iNOS and COX-2 was determined by Western blot, NO by nitrite assay and ...