2-Telraloncs mono-and disubstitutcd with methoxy or hydroxy groups in the aromatic ring are hydrogenated to 2-tetralols in good yields by non-fermenting baker's yeast. The prevalent enantioform of the reduction product and its ee were found to depend on the substitution pattern. In one case, ie the biotransformation of 5-mcthoxy-2-tetralone into the corresponding 2-tetralol, an ee≥ 98% was observed. A simple abstract model for ...
