Studies on syntheses and reactions of methoxypyridazines. I Methoxylation of 3, 4, 5-trichloropyridazine.

H NAGASHIMA, H ODA, JUNI HIDA…

Index: Nagashima, Hiromu; Oda, Hirohisa; Hida, Jun-Ichi; Kaji, Kenji Chemical & Pharmaceutical Bulletin, 1987 , vol. 35, # 1 p. 421 - 424

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Citation Number: 5

Abstract

The reaction of 3, 4, 5-trichloropyridazine (1) with 1 eq amount of NaOMe resulted in the formation of three dichloromonomethoxypyridazines (2, 3-OMe; 3, 4-OMe; 4, 5-OMe) in the ratio of 1: 3: 6. The 4-OMe compound 3 was isolated from the reaction mixture and the 3- OMe compound 2 was synthesized independently. Further methoxylation of 2, 3 and 4 was also investigated in order to prepare various substituted pyridazines.