Enzymatic resolution of α, α-disubstituted α-amino acid esters and amides

…, QB Broxterman, PJH Peters, HE Schoemaker…

Index: Kaptein; Boesten; Broxterman; Peters; Schoemaker; Kamphuis Tetrahedron Asymmetry, 1993 , vol. 4, # 6 p. 1113 - 1116

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Citation Number: 90

Abstract

Abstract The scope and limitations of the enzymatic resolution of α, α-disubstituted α-amino acid amides by an amino acid amidase from Mycobacterium neoaurum and of the corresponding ethyl esteis with Pig liver estetase (PLE) have been studied. Moderate enantiomeric excesses were obtained with PLE, with only a narrow substrate specificity. Mycobacterium neoaurum on the contrary yields a broad range of S-α, α-disubstituted α- ...