New Molecular Markers for Prostate Tumor Imaging: A Study on 2??Methylene Substituted Fatty Acids as New AMACR Inhibitors

…, EA Urusova, C Dinger, E Al??Momani…

Index: Morgenroth, Agnieszka; Urusova, Elizaveta A.; Dinger, Cornelia; Al-Momani, Ehab; Kull, Thomas; Glatting, Gerhard; Frauendorf, Holm; Jahn, Olaf; Mottaghy, Felix M.; Reske, Sven N.; Zlatopolskiy, Boris D. Chemistry - A European Journal, 2011 , vol. 17, # 36 p. 10144 - 10150

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Citation Number: 6

Abstract

Abstract The development of prostate carcinoma is associated with alterations in fatty acid metabolism. α-Methylacyl-CoA racemase (AMACR) is a peroxisomal and mitochondrial enzyme that catalyses interconversion between the (S)/(R)-isomers of a range of α- methylacyl-CoA thioesters. AMACR is involved in the β-oxidation of the dietary branched- chain fatty acids and bile acid intermediates. It is highly expressed in prostate (more than ...