An approach to trapping. gamma.-glutamyl radical intermediates proposed for vitamin K dependent carboxylase:. alpha.,. beta.-methyleneglutamic acid

…, A Simmons, V Lynch, RE Bolger, J Suttie

Index: Slama, James T.; Satsangi, Rajiv K.; Simmons, Anne; Lynch, Vincent; Bolger, Randall E.; Suttie, John Journal of Medicinal Chemistry, 1990 , vol. 33, # 2 p. 824 - 832

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Citation Number: 22

Abstract

Results Synthesis of the a, &Cyclopropane Analogue of Glutamic Acid. a, P-Cyclopropane- containing amino acids have been synthesized by the addition of diazomethane to an unsaturated oxazolone, ls by the addition of diazomethane to the a, P-dehydroamino acid followed by elimination of N2 from the resulting pyrazoline, lg and through the reaction of appropriately substituted and activated methylene compounds with a 1, 2-hal0alkane.~ O ...