Synthesis

3-Acylindoles via a one-pot, regioselective Friedel-Crafts Reaction

JH Wynne, CT Lloyd, SD Jensen, S Boson…

Index: Wynne, James H.; Lloyd, Christopher T.; Jensen, Samuel D.; Boson, Sean; Stalick, Wayne M. Synthesis, 2004 , # 14 p. 2277 - 2282

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Citation Number: 23

Abstract

Abstract Within we report a general one-pot high-yielding Friedel-Crafts acylation of indole using acid chlorides and diethylaluminum chloride in gram scale quantities. This general synthesis affords products that are easily isolated and require no complex purification procedures.