Mitomycin C analogs with aryl substituents on the 7-amino group

…, BS Iyengar, SE Tarnow, WA Remers…

Index: Sami, Salah M.; Iyengar, Bhashyam S.; Tarnow, Shirley E.; Remers, William A.; Bradner, William T.; Schurig, John E. Journal of Medicinal Chemistry, 1984 , vol. 27, # 5 p. 701 - 708

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Citation Number: 45

Abstract

A series of 30 different N7-phenyl-substituted mitomycin C analogues, including 25 new compounds, was prepared from mitomycin A. Seven of these compounds were clearly superior to mitomycin C in activity against P-388 murine leukemia. The para-and the meta- substituted derivatives were subjected to Hansch analysis, which revealed that the lipid- water distribution coefficient 7~ was the only significant factor in determining antitumor ...