Novel quinolinequinone antitumor agents: structure-metabolism studies with NAD (P) H: quinone oxidoreductase (NQO1)

T Fryatt, HI Pettersson, WT Gardipee, KC Bray…

Index: Fryatt, Tara; Pettersson, Hanna I.; Gardipee, Walter T.; Bray, Kurtis C.; Green, Stephen J.; Slawin, Alexandra M. Z.; Beall, Howard D.; Moody, Christopher J. Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 7 p. 1667 - 1687

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Citation Number: 57

Abstract

A series of quinolinequinones bearing various substituents has been synthesized, and the effects of substituents on the metabolism of the quinones by recombinant human NAD (P) H: quinone oxidoreductase (hNQO1) was studied. A range of quinolinequinones were selected for study, and were specifically designed to probe the effects of aryl substituents at C-2. A range of 28 quinolinequinones 2–29 was prepared using three general strategies: the ...