Tetrahedron Letters

Microwave-assisted simple synthesis of quinolines from anilines and alkyl vinyl ketones on the surface of silica gel in the presence of indium (III) chloride

BC Ranu, A Hajra, U Jana

Index: Ranu, Brindaban C.; Hajra, Alakananda; Jana, Umasish Tetrahedron Letters, 2000 , vol. 41, # 4 p. 531 - 533

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Citation Number: 161

Abstract

The synthesis of quinolines and their derivatives has been of considerable interest to organic and medicinal chemists for many years as a large number of natural products 1 and drugs 2 contain this heterocyclic nucleus. The classical method for quinoline synthesis involves Skraup's procedure. 3 However, it requires a large amount of sulfuric acid at temperatures above 150°C and the reaction is often violent. Since then, many methods have been developed ...