Heterocycles

Copper-catalyzed N-arylation of 2-oxazolidinones. An expeditious route to toloxatone

S Cacchi, G Fabrizi, A Goggiamani

Index: Cacchi, Sandro; Fabrizi, Giancarlo; Goggiamani, Antonella Heterocycles, 2003 , vol. 61, p. 505 - 512

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Citation Number: 4

Abstract

Abstract 3-Aryl-2-oxazolidinones are obtained in excellent yields through the copper- catalyzed N-arylation of 2-oxazolidinones with a variety of aryl iodides. With aryl halides containing both iodo and bromo substituents, a high CI/C-Br selectivity can be achieved. The procedure has been successfully applied to the preparation of a key intermediate in the synthesis of linezolid and to develop an expeditious route to toloxatone.