Abstract: Novel cADPR mimics, which integrate nucleobase, northern and southern ribose modifications were synthesized. The key steps of the synthesis were a Cu (I)-catalyzed Hüisgen [3+ 2] cycloaddition and a microwave-assisted intramolecular pyrophosphorylation. Preliminary biological investigations showed that these cADPR mimics are membrane- permeating agonists of the calcium signaling pathway. The introduction of chlorine or ...
