Journal of the American Chemical Society

Synthesis of cyclic enones via direct palladium-catalyzed aerobic dehydrogenation of ketones

T Diao, SS Stahl

Index: Diao, Tianning; Stahl, Shannon S. Journal of the American Chemical Society, 2011 , vol. 133, # 37 p. 14566 - 14569

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Citation Number: 137

Abstract

α, β-Unsaturated carbonyl compounds are versatile intermediates in the synthesis of pharmaceuticals and biologically active compounds. Here, we report the discovery and application of Pd (DMSO) 2 (TFA) 2 as a catalyst for direct dehydrogenation of cyclohexanones and other cyclic ketones to the corresponding enones, using O2 as the oxidant. The substrate scope includes heterocyclic ketones and several natural-product ...