Tetrahedron

Improvement and simplification of synthesis of 3-aryloxy-1, 2-epoxypropanes using solvent-free conditions and microwave irradiations. Relation with medium effects …

BK Pchelka, A Loupy, A Petit

Index: Pchelka, Beata K.; Loupy, Andre; Petit, Alain Tetrahedron, 2006 , vol. 62, # 47 p. 10968 - 10979

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Citation Number: 42

Abstract

Some 3-aryloxy-1, 2-epoxypropanes, interesting as potential synthons in β-adrenergic receptor antagonists preparation, were obtained in excellent yields (65–96% within 2– 17min) by microwave activation (monomode system) using solid–liquid solvent-free phase transfer catalysis (PTC). The best results for the O-alkylation of some phenols with epichlorohydrin were obtained using TBAB and NaOH/K2CO3 (1: 4mol/mol) as phase ...