A systematic study on the chemical stability of mitomycin A and mitomycin B.

JH BEIJNEN, OAGJ VAN DER HOUWEN…

Index: Beijnen; Van der Houwen; Rosing; Underberg Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 7 p. 2900 - 2913

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Citation Number: 16

Abstract

The kinetics and mechanisms of the degradation of mitomycin A and mitomycin B in aqueous solution were investigated by means of ultraviolet (UV) spectrophotometry and high-performance liquid chromatography (HPLC). The influences of pH, buffers and temperature on the degradation were quantified. Degradation products were isolated and characterized by mass spectrometry (MS), UV-VIS spectrophotometry, chromatography ...