Guerbet reaction of primary alcohols leading to β-alkylated dimer alcohols catalyzed by iridium complexes

T Matsu-Ura, S Sakaguchi, Y Obora…

Index: Matsu-Ura, Toyomi; Sakaguchi, Satoshi; Obora, Yasushi; Ishii, Yasutaka Journal of Organic Chemistry, 2006 , vol. 71, # 21 p. 8306 - 8308

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Citation Number: 84

Abstract

[IrCl (cod)] 2 and [Cp* IrCl2] 2 complexes catalyzed efficiently the Guerbet reaction of primary alcohols to β-alkylated dimer alcohols in good yields. For instance, the reaction of 1- butanol in the presence of [Cp* IrCl2] 2 (1 mol%), t-BuOK (40 mol%), and 1, 7-octadiene (10 mol%) produced 2-ethyl-1-hexanol in 93% yield. Various primary alcohols undergo the Guerbet reaction under the influence of Ir complexes to give the corresponding dimer ...