Various derivatives of 2-aryl-3-hydroxy-2, 3-dihydro-1, 5-benzothiazepin-4 (5H)-one (I) were synthesized. Alternative routes to 2-aryl-3-hydroxy-5-alkyl-trans-2, 3-dihydro-1, 5- benzothiazepin-4 (5H)-one (II-β) and 2-aryl-3-acetoxy-5-dimethylaminoethyl-cis-2, 3-dihydro- 1, 5-benzothiazepin-4 (5H)-one (VI-α) were also investigated respectively.
![3-hydroxy-2-phenyl-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one Structure](https://image.chemsrc.com/caspic/055/27068-82-2.png)
![3-acetoxy-2-phenyl-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one Structure](https://image.chemsrc.com/caspic/341/31966-80-0.png)