In our studies on the development of new anticonvulsants, we planned the synthesis of N- substituted 1, 2, 3, 4-tetrahydroisoquinolines to explore the structure-activity relationships. All derivatives were evaluated against audiogenic seizures in DBA/2 mice, and the 1-(4'- bromophenyl)-6, 7-dimethoxy-2-(piperidin-1-ylacetyl) derivative (26) showed the highest activity with a potency comparable to that of talampanel, the only noncompetitive α-amino- ...
