Transesterification of trimethyl orthoacetate: an efficient protocol for the synthesis of 4-alkoxy-2-aminothiophene-3-carbonitriles

KV Rao, C Balakumar, BL Narayana, DP Kishore…

Index: Venkata Rao; Balakumar; Lakshmi Narayana; Pran Kishore; Rajwinder; Raghuram Rao Tetrahedron Letters, 2013 , vol. 54, # 10 p. 1274 - 1278

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Citation Number: 3

Abstract

A facile one-pot method is reported for the synthesis of 4-alkoxy-2-aminothiophene-3- carbonitriles. Transesterification of trimethylorthoacetate technique allowed introducing alkoxy substituents into 2-aminothiophene ring system. Diverse alkoxy substituents could be introduced efficiently by using this methodology. Further the synthesis of some of new 4- alkylamino-2-aminothiophenes is also reported.