Palladium-Catalyzed Double and Single Carbonylations of. BETA.-Amino Alcohols. Selective Synthesis of Morpholine-2, 3-diones and Oxazolidin-2-ones and …

…, Y Mitsue, K Ike, K Washizuka, SI Murahashi

Index: Imada, Yasushi; Mitsue, Yo; Ike, Kazuo; Washizuka, Ken-Ichi; Murahashi, Shun-Ichi Bulletin of the Chemical Society of Japan, 1996 , vol. 69, # 7 p. 2079 - 2090

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Citation Number: 49

Abstract

Catalytic cross double carbonylation of secondary amines and alcohols proceeds in the presence of [PdCl 2 (MeCN) 2] and CuI under carbon monoxide (80 atm) and oxygen (5 atm). Catalytic intramolecular double carbonylation of β-amino alcohols gives morpholine-2, 3-diones, which are excellent protecting compounds of amino alcohols and important precursors for biologically active nitrogen compounds. In contrast, catalytic single ...