Tetrahedron Letters

Regioselective monobromination of (E)-1-(2′-hydroxy-4′, 6′-dimethoxyphenyl)-3-aryl-2-propen-1-ones using bromodimethylsulfonium bromide and synthesis of 8- …

AT Khan, A Choudhury, S Ali, MM Khan

Index: Khan, Abu T.; Choudhury, Abhik; Ali, Shahzad; Musawwer Khan, Md. Tetrahedron Letters, 2012 , vol. 53, # 36 p. 4852 - 4857

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Citation Number: 7

Abstract

A wide variety of monobrominated compounds 2a–l have been prepared in good yields from (E)-1-(2′-hydroxy-4′, 6′-dimethoxyphenyl)-3-aryl-2-propen-1-ones (1a–l) through regioselective ring bromination using 1.5 equiv of bromodimethylsulfonium bromide (BDMS) at room temperature. Similarly, some of the 2′-hydroxychalcones can be converted directly into tribromides 3 or dibromides 4 by employing 4.0 equiv of BDMS under different ...