Synthesis of hippuric acid amides and coumarin derivatives. Effect of N, N-diethylacetamide

SI Zav'yalov, OV Dorofeeva, EE Rumyantseva…

Index: Zav'yalov; Dorofeeva; Rumyantseva; Kulikova; Ezhova; Kravchenko; Zavozin Pharmaceutical Chemistry Journal, 1999 , vol. 33, # 6 p. 328 - 330

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Abstract

Hippuric acid amides are used as semiproducts in the synthesis of oxazole derivatives possessing antidepressant activity [1]. According to [2-7], these compounds are obtained by azlactonation ofhippuric acid (I) under the action of acetic anhydride, followed by condensation of the intermediate product, 2-phenyl-2-oxazolin-5-one (II), with amines in tetrahydrofuran or benzene (or without solvent). The azlactonation of compound I is not a ...