Palladium-catalyzed method for the synthesis of carbazoles via tandem C− H functionalization and C− N bond formation

…, G Brasche, N Zheng, SL Buchwald

Index: Tsang, W. C. Peter; Munday, Rachel H.; Brasche, Gordon; Zheng, Nan; Buchwald, Stephen L. Journal of Organic Chemistry, 2008 , vol. 73, # 19 p. 7603 - 7610

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Citation Number: 195

Abstract

The development of a new method for the assembly of unsymmetrical carbazoles is reported. The strategy involves the selective intramolecular functionalization of an arene CH bond and the formation of a new arene CN bond. The substitution pattern of the carbazole product can be controlled by the design of the biaryl amide substrate, and the method is compatible with a variety of functional groups. The utility of the new protocol was ...