Mechanistic studies on dopamine. beta.-monooxygenase catalysis: N-dealkylation and mechanism-based inhibition by benzylic-nitrogen-containing compounds. …

K Wimalasena, SW May

Index: Wimalasena, Kandatege; May, Sheldon W. Journal of the American Chemical Society, 1987 , vol. 109, # 13 p. 4036 - 4046

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Citation Number: 46

Abstract

Abstract: Dopamine 0-monooxygenase (DBM) 63 readily catalyzes oxidative N-dealkylation of N-phenylethylenediamine (PEDA) and N-methyl-N-phenylethylenediamine (N-MePEDA) with the reaction characteristics expected for a monooxygenase-catalyzed process. The products of this reaction have been quantitatively identified as aniline (or N-methylaniline for N-MePEDA) and 2-aminoacetaldehyde, the latter compound being successfully trapped ...