The chemistry of 3??azaisotoic anhydrides. Synthesis and reactions of polyaza heterocycles

GM Coppola, JD Fraser, GE Hardtmann…

Index: Coppola, Gary M.; Fraser, James D.; Hardtmann, Goetz E.; Shapiro, Michael J. Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 193 - 206

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Citation Number: 21

Abstract

Abstract The preparation of a variety of N-substituted 3-azaisatoic anhydrides 3 and 8 is described. These anhydrides reacted with thiopseudoureas to give interesting bicyclic, tricyclic, and tetracyclic heterocycles many of which are new ring systems. One such heterocycle, the imidazo [1, 2-a] pyrido [2, 3-d] pyrimidine ring system, was studied further with respect to alkylation and reduction reactions. Alkylation of 12h occurred on the ...