RSC Advances

Expanding the scaffold for bacterial RNA polymerase inhibitors: design, synthesis and structure–activity relationships of ureido-heterocyclic-carboxylic acids

WAM Elgaher, M Fruth, M Groh, J Haupenthal…

Index: RSC Advances, , vol. 4, # 5 p. 2177 - 2194

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Citation Number: 7

Abstract

... DOI: 10.1039/C3RA45820B (Paper) RSC Adv., 2014, 4 ... of the parent class I. 17 An increase of activity was also observed with substituents having larger hydrophobic volume at the ... Spontaneous resistance rate towards Myx B in S. aureus was found to be 4 to 7 × 10 −8 , similar to ...