Substituted pyrazolones require N 2 hydrogen bond donating ability to protect against cytotoxicity from protein aggregation of mutant superoxide dismutase 1

…, R Benmohamed, DR Kirsch, RB Silverman

Index: Trippier, Paul C.; Benmohammed, Radhia; Kirsch, Donald R.; Silverman, Richard B. Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 21 p. 6647 - 6650

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Citation Number: 10

Abstract

Amyotrophic lateral sclerosis (ALS) is a debilitating and fatal neurodegenerative disease. Although the cause remains unknown, misfolded protein aggregates are seen in neurons of sporadic ALS patients, and familial ALS mutations, including mutations in superoxide dismutase 1 (SOD1), produce proteins with an increased propensity to misfold and aggregate. A structure activity relationship of a lead scaffold exhibiting neuroprotective ...