Bull. Soc. Chim Fr

Synthesis of (S)-fenfluramine from (R) or (S) 1-[3-(trifluoromethyl) phenyl] propan-2-ol

B Goument, L Duhamel, R Maugé

Index: Goument, B.; Duhamel, L.; Mauge, R. Bulletin de la Societe Chimique de France, 1993 , vol. 130, p. 450 - 458

Full Text: HTML

Citation Number: 3

Abstract

Summary-Syntheses of (S)-fenfluramine from (R) or (S)-1-[3-(trifluoromethyl) phenyl] propan- 2-ol.(R) and (S)--1-[3-(trifluoromethyl) phenyl] propan-2-ol 3 are useful intermediates in the synthesis of fenfluramine (S)-1. They can be obtained from optically active propylene oxide (R) or (S)-7. The alcohol (R)-3 was transformed in two steps into (S)-fenfluramine using the action of ethylamine on a sulfonate (R)-4. We describe a new one-pot synthesis for (S)- ...