Synthesen auf der Basis von 2??Oxoglutarsäure. II Zur Synthese von Heterocyclen durch Reaktionen von 3??Brom??2??oxoglutarsäuredimethylester mit Binucleophilen

H Hartenstein, T Blitzke, D Sicker…

Index: Hartenstein, H.; Blitzke, T.; Sicker, D.; Wilde, H. Journal fuer Praktische Chemie/Chemiker-Zeitung, 1993 , vol. 335, # 2 p. 176 - 180

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Citation Number: 10

Abstract

Abstract. Reactions of dimethyl 3-bromo-2-oxo- the bromine atom and form 2- aminothiazoles 3-7 glutarate 2 with binucleophiles to form heterocycles and the 1, 3, 4- thiadiazine 8. However, o-phenylenproceed on two different pathways depending on the diamines reacted to form the brominated quinoxalinetype of reactant. Thus, strong S- nucleophiles like 2 (1H)-one derivatives 9 and 10, resp. thioureas and thiocarbohydrazide ...