Synthetic Communications

Concise Synthesis and X-Ray Crystal Structure of N-Benzyl-2-(pyrimidin-4′-ylamino)-thiazole-4-carboxamide (Thiazovivin), a Small-Molecule Tool for Stem Cell …

…, M Granitzka, D Stalke, C Ducho

Index: Ries, Oliver; Granitzka, Markus; Stalke, Dietmar; Ducho, Christian Synthetic Communications, 2013 , vol. 43, # 21 p. 2876 - 2882

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Abstract

Stem cell research is one of the most promising fields of modern biomedical research and regenerative medicine. Limited availability and ethical concerns suggest the renouncement of embryonic stem cells (ESCs), thus raising the need for more efficient procedures for the generation of stem cells, ideally through reprogramming of mammalian cells. The small molecule N-benzyl-2-(pyrimidin -4′-ylamino)-thiazole-4-carboxamide (thiazovivin) is known to improve the generation of ...