Access to (S)-2-methyloxetane and the precursor (S)-1, 3-butanediol of high enantiomeric purity

…, B Koppenhoefer, V Schurig

Index: Hintzer, Klaus; Koppenhoefer, Bernhard; Schurig, Volker Journal of Organic Chemistry, 1982 , vol. 47, # 20 p. 3850 - 3854

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Citation Number: 46

Abstract

(S)-2-Methyloxetane (1) and its precursor (S)-1, 3-butanediol (2) were prepared in low to moderate chemical yield with less than 0.5% racemization from (S)-ethyl lactate (4) and from (2S, 3S)-allothreonine (14b). For the first time the enantiomeric purities of both the starting material and the product (1) were carefully determined by high-precision capillary gas chromatography on optically active resolving stationary phases. The validity of the ...

~48%

~83%

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