Synthetic Communications

A convenient synthesis of 3-alkylthiophenes

CV Pham, HB Mark Jr, H Zimmer

Index: Pham, Chiem Van; Mark, Harry B.; Zimmer, Hans Synthetic Communications, 1986 , vol. 16, # 6 p. 689 - 696

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Citation Number: 129

Abstract

Abstract The known procedures for the synthesis of 3-alkylthiophenes are rather lengthy or involved. By using the NiDPPP++ catalyzed cross-coupling method between 3- bromothiophene and Grignard reagents derived from alkyl halides a number of 3- alkylthiophenes have been prepared in a one-step reaction in good to excellent yields.